https://www.sierrajournals.com/index.php/IJAPSR/issue/feed 2026-07-23T06:55:31+00:00 Editor-in-chief editor_ijapsr@sierrajournals.com Open Journal Systems <div class="row"> <div class="col-md-4 text-center"><img src="/public/site/images/sjadmin/IJAPSR.jpg"></div> <div class="col-md-8"> <p>IJAPSR is a peer-reviewed, open-access journal published quarterly by Sierra Journals Publisher. The journal publishes original work like a research article, review article, case study, short communication, and letter to the editor. The journal covers various subjects related to pharmaceutical and applied sciences.</p> <p>The journal aims to promote basic research into clinical investigation and convert clinical evidence into practical knowledge. We encourage papers referring to global medical studies of human health.</p> <p>Sierra Journals Publisher is a member of Crossref, thus the journal provides digital object identifier, LOCKSS preservation for its content followed by indexing in good indexing agencies</p> <p>&nbsp;</p> </div> </div> <div class="row"> <div id="additionalHomeContent" class="col-md-12"> <p>ISSN NO: 2455-8095&nbsp;&nbsp;&nbsp;&nbsp; Doi prefix: 10.21477&nbsp;&nbsp; &nbsp;</p> &nbsp;&nbsp; <div id="myCarousel" class="carousel slide"><!-- Carousel items --> <div class="carousel-inner"> <div class="item active"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="https://cassi.cas.org/publication.jsp?P=eCQtRPJo9AQyz133K_ll3zLPXfcr-WXfjt0X0_xdyEaV-bwOhGasxnN7lh7zdprwl4tOMjXTf3K68Jej_HbA1_v0Fw-HwGxve7u5MBdRGQtGHlwLud12iZCqOAU4FEyOMs9d9yv5Zd8yz133K_ll31097aObglrVMs9d9yv5Zd8yz133K_ll3-PwQmCb93Me38ynJvD8BQo" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo15.png"></a></div> <div class="col-md-3 col-xs-6"><a href="https://www.citefactor.org/journal/index/16689/international-journal-of-applied-pharmaceutical-sciences-and-research#.XwshaigzbIU" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo21.png"></a></div> <div class="col-md-3 col-xs-6"><a href="https://scholar.google.co.in/scholar?hl=en&amp;q=international+journal+of+applied+pharmaceutical+sciences+and+research&amp;btnG=" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo31.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo53.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="http://journalseeker.researchbib.com/view/issn/2455-8095" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo71.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo83.png"></div> <div class="col-md-3 col-xs-6"><a href="https://www.scilit.net/journals/426813" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo91.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo111.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="https://www.worldcat.org/libraries/195403?backfrom=libraryProfile&amp;searchTerm=International%20Journal%20of%20Applied%20Pharmaceutical%20Sciences%20and%20Research&amp;start=1&amp;count=10&amp;libTypeNum=0&amp;sortBy=rel" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo121.png"></a></div> <div class="col-md-3 col-xs-6"><a href="https://explore.openaire.eu/search/dataprovider?datasourceId=openaire____::5b8a4fdab547dfde370881702ab24816" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo131.png"></a></div> <div class="col-md-3 col-xs-6"><a href="https://www.openarchives.org/Register/BrowseSites?viewRecord=http://www.sierrajournals.com/direct/index.php/IJAPSR/oai" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo41.png"></a></div> </div> <!--/row-fluid--></div> <!--/item--></div> <!--/carousel-inner--> <a class="left carousel-control" href="#myCarousel" data-slide="prev">‹</a> <a class="right carousel-control" href="#myCarousel" data-slide="next">›</a></div> <!--/myCarousel--></div> </div> https://www.sierrajournals.com/index.php/IJAPSR/article/view/1130 2026-07-23T06:55:31+00:00 Sameer Makkar Drsameermakkar@yahoo.com

<p>Regenerative endodontics has emerged as a biologically driven approach for preserving natural teeth by restoring<br>the vitality and function of the pulp–dentin complex. Among the most promising regenerative strategies<br>are stem cell-derived extracellular vesicles (EVs) and platelet-rich fibrin (PRF), both of which provide bioactive<br>molecules that promote tissue repair and regeneration through distinct mechanisms. Stem cell-derived EVs<br>represent a cell-free therapeutic modality capable of enhancing intercellular communication, angiogenesis,<br>immunomodulation, neurogenesis, and odontogenic differentiation while minimizing concerns associated with<br>direct stem cell transplantation. PRF, an autologous platelet concentrate, serves as a natural scaffold that gradually<br>releases growth factors to support wound healing, stem cell recruitment, vascularization, and periapical<br>tissue regeneration. This review evaluates the biological characteristics, mechanisms of action, regenerative<br>potential, clinical applications, advantages, and limitations of stem cell-derived EVs and PRF in regenerative<br>endodontics. It also highlights current evidence regarding their comparative therapeutic performance, discusses<br>challenges related to clinical translation, and explores future directions, including biomaterial integration<br>and artificial intelligence-assisted treatment evaluation. Both approaches demonstrate considerable promise<br>for improving regenerative outcomes, although further standardized clinical studies are required to establish<br>optimal therapeutic protocols and long-term clinical efficacy.</p>

2026-07-20T00:00:00+00:00 Copyright (c) 2026