Evaluation of Antibacterial and Anti Fungal Activity of Hexane and Methanol Extracts of Psoralea Corylifolea Seed

Sharath K, Krishna Mohan G, Sandhya Rani M, Kowmudi V, Suresh N


Objective: To evaluate antibacterial and antifungal activity of hexane and methanol extracts of Psoralea Corylifolea Seed.

Method: Psoralea Corylifolia seeds were extracted by using different solvents hexane and methanol and the test extracts were assayed for antibacterial and antifungal activity. The antibacterial activity was tested against Staphylococcus aureus and antifungal activity was tested against Candida albicans and Aspergillus niger by agar well diffusion method and measuring the zone of Inhibition.Results: The hexane and methanol extracts of Psoralea corylifolia seed was very effective against Staphylococcus aureus, Candida albicans and Aspergillus niger. The results showed unique characters of the plant in inhibiting bacterial and fungal growth.Conclusion: In the present study antibacterial and anti fungal activity of hexane and methanol extracts of psoralea corylifolea seed was confirmed.



Evaluation; Antibacterial; Anti Fungal; Activity; Hexane; Methanol; Extracts; Psoralea Corylifolea; Seed;

Full Text:



Abubakar MG, Yerima MB, Zahriya AG and Ukwuani AN (2010). Acute toxicity and antifungal studies of ethanolic leaves, stem and pulp extact of Tamarindus Indica. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 1(4), 104-111.

Ahmad I, Aqil F (2007). In vitro efficacy of bioactive extracts of 15 medicinal plants against ESbL-producing multidrug-resistant enteric bacteria. 162, 264-75.

Barbour EK, Al Sharif M, Sagherian VK, Habre AN, Talhouk RS, Talhouk SN (2004). Screening of selected indigenous plants of Lebanon for antimicrobial activity. J Ethnopharmacol. 93, 1-7.

Bibitha B, Jisha V.K, Salitha C.V, Mohan S and Valsa A.K.Antibacterial activity of different plants extracts (2002). Indian J Microbiol. 42, 361-363.

Bina Gidwani et al (2010), Anti-inflammatory and antimicrobial activity of hexane extract of seed of psoralea corylifoliaLinn, International Journal of Pharma Research and Development. 10(2), 129-137.

Das K, Tiwari, RK. and Shrivastava DK (2010). Techniques for evaluation of medicinal plant products as antimicrobial agent: Current methods and future trends. Journal of Medicinal Plants Research. 4, 104-11.

Iwu MW, Duncan AR, Okunji CO (1999). New antimicrobials of plant origin In:Perspectives on new Crops and new Uses, eds. J. Janick, ASHS Press:Alexandria, VA. p. 457-/62.

Latha SP, Kannabiran K (2006). Antimicrobial activity and phytochemicals of Solanum trinobatum linn. Afri. J Biotechnol. 5(3), 2402-2012.

Latha PG, Evans DA, Panikkar KR, Jayavardhanan KK (2000). Immunomodulatory and anti-tumour properties of Psoralea corylifolia seeds. Fitoterapia . 7, 223- 231.

Latha PG, Panikkar KR (1999). Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds. Journal of Ethnopharmacology. 68, 295-298.

Munir Anwar, Mansoor Ahmad, Mehjabeen, Noor Jahan, Omair A. Mohiuddin and Mahmood Qureshi (2011). African Journal of Pharmacy and Pharmacology. Vol. 5(23), pp. 2627-2638.

Nair R, Chanda S (2006). Activity of some medicinal plants against certain pathogenic bacterial strains. Indian J Pharmacol. 38, 142-4.

Napoleon Arumugam, Sasikumar Kandasamy, M. Sekar (2012). In-vitro Antifugal activity of Hybanthus Enneaspermus F Muell. International Journal of Pharmacy and Pharmaceutical Sciences. 4(2), 594-596.

Nickavar B, Alinaghi A, Khalinejad M (2008). Iranian J Pharm Res. 7(3), 203-209.

Okeke IN, Laxmaninarayan R, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF (2005). Antimicrobial resistance in developing countries. Part 1: recent trends and current status. J Lancet Infect Dis. 5,481-93.

Prasad NR, Anand C, Balasubramanian S, Pugalendi KV (2004). Antidermatophytic activity ofextracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound. Journal of Ethnopharmacology . 91, 21-24.

Siddhinandan Mishra., Bhiashajya Ratnavali Chaukhambha (2009) Publication Varanasi. 54, 353-35, Khadirarishta- Kushtharogadhikar.

Sindhu G (2009). Antibacterial and antifungal studies of Abutilon indicum leaf extract. Pharmacol. 2, 567571.

Soulsby EJ (2005). Resistance to antimicrobials in humans and animals. Brit J Med. 331, 1219-20.

Szollosi R, Szollosi Vagra I (2002), Acta Biologica Szegediensis. 46(3-4), 125-7.

Qamaruddin A, Parveen N, Khan NU, Singhal KC (2003). Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setariacervi. Journal of EthnopharmacologY. 84(2-3): 313.

Y. Wang, C. Hong, C. Zhou, D. Xu, and H. B. Qu (2011). “Screening antitumor compounds psoralen and isopsoralen from Psoralea corylifolia L. seeds,” Evidence-based Complementary and Alternative Medicine. vol. 2011, Article ID 363052 .

Zhang CZ, Wang SX, Zhang Y, Chen JP, Liang XM (2005). In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Journal of Ethnopharmacology. 98, 295-300.

DOI: http://dx.doi.org/10.21477/ijapsr.v1i1.9605


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a creativecommons.org/licenses/by/4.0/. https://creativecommons.org/licenses/by/4.0/
Based on a work at http://www.sierrajournals.com/direct/index.php/IJAPSR/issue/archive