Comparative study of coagulation effect of Diospyros Malabarica

N. S. Abegunasekara, A.M.A. G.K.S. Bandara

Abstract


A simple, sensitive, economical UV Spectrophotometric method was developed for the simultaneous estimation of Lornoxicam and Paracetamol in bulk and tablet formulation by using Urea solution as Hydrotropic agent. The max for Lornoxicam and Paracetamol was found to be 384 nm and 244 nm respectively and both Lornoxicam and Paracetamol obey Beer-Lambert’s law in the concentration range of 2-10 µg/ml (r2=0.999) and 20-60 µg/ml.(r2=0.999) in 8M Urea(Hydrotropic agent) respectively. The developed method was validated according to ICH guidelines and value of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values.

Keywords


Method Development, Validation, Simultaneous Estimation, Lornoxicam, Paracetamol, UV Spectrophotometry, Hydrotropic Agents.

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DOI: http://dx.doi.org/10.21477/ijapsr.4.3.2

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International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a creativecommons.org/licenses/by/4.0/. https://creativecommons.org/licenses/by/4.0/
Based on a work at http://www.sierrajournals.com/direct/index.php/IJAPSR/issue/archive