A Rare Case of Male Breast Metastasis from Previously Removed Renal Cell Carcinoma

Stefania Erra, Simone Lo Mastro, Silvio Modena


Renal cell carcinoma (RCC) is the most lethal pathology affecting the urinary system, especially in people over 65 years and with an incidence of about 2% per year. RCC can be classified according to histological findings, cytogenetic abnormalities, biological features and response to therapy. This article reports an extremely rare case of clear cell RCC in a 73 years old male patient with metastasis in the breast and in the bronchi, presented 15 years after surgical resection of primitive renal tumor. 


Renal cell carcinoma; breast metastasis; bronchial metastasis;

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A Leonetti, F Leonardi, M Bersanelli and S Buti (2017). Clinical use of lenvatinib in combination with everolimus for the treatment of advanced renal cell carcinoma. Ther. Clin. Risk. Manag. 13:799–806.

Amin MB, Tamboli P, Javidan J, Stricker Het al., (2002). Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am. J. Surg. Pathol. 26:281-291.

Eble JN, Sauter G, Epstein JI, Sesterhenn IA (2004). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and male Genital Organs. Lyon: IARC Press.

Gurel S, Narra V, Elsayes KM, Siegel CL, Chen ZE, Brown JJ (2013). Subtypes of renal cell carcinoma: MRI and pathological features. Diagn. Interv. Radiol. 19: 304-311. DOI: 10.5152/dir.2013.147.

Iacovelli R, Ciccarese C, Bria E, Bimbatti D et al., (2018). Immunotherapy versus standard of care in metastatic renal cell carcinoma. A systematic review and meta-analysis. Cancer Treatment Reviews. 70:112-117. doi: 10.1016/j.ctrv.2018.08.007.

Jones TD, Eble JN, Cheng L (2005). Application of molecular diagnostic techniques to renal epithelial neoplasms. Clin Lab Med. 25:279-303.

Matsubara N, Naito Y, Nakano K, Fujiwara Y, et al., (2018). Lenvatinib in combination with everolimus in patients with advanced or metastatic renal cell carcinoma: A phase 1 study. Int. J. Urol. doi: 10.1111/iju.13776.

Motzer RJ, Agarwal N, Beard C, Bhayani S et al., (2011). Kidney cancer. J. Natl. Compr. Canc. Netw. 9: 960-977.

Siegel RL, Miller KD, Jemal A (2015). Cancer statistics. CA Cancer J Clin. 65:5-29.

Sükösd F, Kuroda N, Beothe T, Kaur AP, Kovacs G (2003). Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res. 63:455-457.

Tabei T, Tsuura Y, Kobayashi K (2018). Pseudo progression: A case of metastatic renal clear cell carcinoma treated with nivolumab.Pathol. Int. doi: 10.1111/pin.12714.



DOI: http://dx.doi.org/10.21477/ijapsr.3.4.3


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International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a creativecommons.org/licenses/by/4.0/. https://creativecommons.org/licenses/by/4.0/
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