Dictatorial streaming of biomarkers in some diseases

Mohammed Torequl Islam, Thoufiqul Alam Riaz, Jannatul Ferdous, Atiqur Rahaman, Bishwajit Guha, Shashi Mohagon, Abdullah-Al-Mahmud Munna, Asma Akhter, Elora Parijat Parijat


The term "biomarker‟ is used from 1980. Nowadays, diagnosis/prognosis and research in medical science are more concerned with the discovery and utilization of a number of biomarkers. The information in the library of biomarkers is rising day by day as their major concerns relate diseases, pathogenicity or pharmacology in a variety of hosts. Taking into account, we summarize a number of biomarkers in a number of diseases in human. It includes the name and their up- and/or down expressions in those situations. However, no description was plugged with the individual fact.


biomarkers; pathophysiology; up-regulation; down-regulation

Full Text:



Ali AM, DiPersio JF, Schroeder MA (2016). The role of biomarkers in the diagnosis and risk stratification of acute graft-versus-host disease: A systematic review. Biol Blood Marrow Transplant. 2016:1-13. doi.org/10.1016/j.bbmt.2016.04.022.

Altintas Z, Tothill I (2013). Biomarkers and biosensors for the early diagnosis of lung cancer. Sensors Actuators B. 188:988-998. doi.org/10.1016/j.snb.2013.07.078.

An M, Gao Y (2015). Urinary biomarkers of brain diseases. Genom Proteom Bioinformat. 13:345-54. doi.org/10.1016/j.gpb.2015.08.005.

Azkargorta M, Soria J, Acera A, et al (2016). Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice. J Proteomics. doi.org/10.1016/j.jprot.2016.05.006.

Bakkar N, Boehringer A, Bowser R (2015). Use of biomarkers in ALS drug development and clinical trials. Brain Res. 1607:94-107. doi.org/10.1016/j.brainres.2014.10.031.

Bedreag OH, Rogobete AF, Dumache R, et al (2015). Use of circulating microRNAs as biomarkers in critically ill polytrauma patients. Biomarkers Genomic Med. 7:131-8. doi.org/10.1016/j.bgm.2015.11.002.

Belcher JM (2015). Acute kidney injury in liver disease: Role of biomarkers. Adv Chronic Kidney Dis. 22:368-75. doi.org/10.1053/j.ackd.2015.06.009.

Blennow K, Dubois B, Fagan AM, et al (2015). Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer‟s disease. Alzheimer’s Dementia. 11:58-69. doi.org/10.1016/j.jalz.2014.02.004.

Bostick RM (2015). Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms. J Steroid Biochem Molecul Biol. 148:86-95. doi.org/10.1016/j.jsbmb.2015.01.010.

Buchbinder EI, Flaherty ET (2016). Biomarkers in melanoma: Lessons from translational medicine. Trends Cancer. 17:1-8. doi.org/10.1016/j.trecan.2016.05.003.

Casanova N, Zhou T, Knox KS, et al (2015). Identifying novel biomarkers in sarcoidosis using genome-based approaches. Clin Chest Med. 36:621-30. doi.org/10.1016/j.ccm.2015.08.005.

Chae YK, Pan A, Davis AA, Raparia K, et al (2016). Biomarkers for PD-1/PD-L1 blockade therapy in non-small-cell lung cancer: Is PD-L1 expression a good marker for patient selection? Clin Lung Cancer. doi.org/10.1016/j.cllc.2016.03.011.

Chora I, Guiducci S, Manetti M, et al (2015). Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis. Autoimmun Rev. 14:314-22. doi.org/10.1016/j.autrev.2014.12.001.

Cruz CD, Coelho A, Antunes-Lopes T, et al (2015). Biomarkers of spinal cord injury and ensuing bladder dysfunction. Advanced Drug Delivery Rev. 82–83:153-9. doi.org/10.1016/j.addr.2014.11.007.

Damanhouri GA, Jarullah J, Marouf S, et al (2015). Clinical biomarkers in sickle cell disease. Saudi J Biol Sci. 22:24-31. doi.org/10.1016/j.sjbs.2014.09.005.

D'Ambrosio A, Pontecorvo S, Colasanti T, et al (2015). Peripheral blood biomarkers in multiple sclerosis. Autoimmun Rev. 14: 1097-110. doi.org/10.1016/j.autrev.2015.07.014.

Dasari S, Wudayagiri R, Valluru L (2015). Cervical cancer: Biomarkers for diagnosis and treatment. Clin Chim Acta. 445:7-11. doi.org/10.1016/j.cca.2015.03.005.

Delanghe JR, Speeckaert MM (2015). Translational research and biomarkers in neonatal sepsis. Clin Chim Acta. 451: 46-64. doi.org/10.1016/j.cca.2015.01.031.

Dix A, Vlaic S, Guthke R, et al (2016). Use of systems biology to decipher host–pathogen interaction networks and predict biomarkers. Clin Microbiol Infect. doi.org/10.1016/j.cmi.2016.04.014.

Dixit AB, Tripathi M, Chandra PS, et al (2015). Molecular biomarkers in drug-resistant epilepsy: Facts & possibilities. Int J Surgery. 1-9. doi.org/10.1016/j.ijsu.2015.08.029.

Francoz C, Nadim MK, Durand F (2016). Kidney biomarkers in cirrhosis. J Hepatol. doi.org/10.1016/j.jhep.2016.05.025.

Galano J-M, Lee JC-Y, Gladine C, et al (2015). Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers. Biochim Biophys Acta. 1851:446-55. doi.org/10.1016/j.bbalip.2014.11.004.

Goff DC, Romero K, Paul J, Perez-Rodriguez MM, et al (2016). Biomarkers for drug development in early psychosis: Current issues and promising directions. Eur Neuropsychopharmacol. doi.org/10.1016/j.euroneuro.2016.01.009.

Goules AV, Tzioufas AG (2016). Primary Sjӧgren's syndrome: Clinical phenotypes, outcome and the development of biomarkers. Autoimmun Rev. 15:695-703. doi.org/10.1016/j.autrev.2016.03.004.

Grazia R, Matteo R, Yannis P, et al (2016). Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis. Psychiatr Res. 241:207-20. doi.org/10.1016/j.psychres.2016.04.117.

Grivas PD, Melas M, Papavassiliou AG (2015). The biological complexity of urothelial carcinoma: Insights into carcinogenesis, targets and biomarkers of response to therapeutic approaches. Seminars Cancer Biol. 35:125-32. doi.org/10.1016/j.semcancer.2015.08.006.

Gururajan A, Clarke G, Dinan TG, et al (2016). Molecular biomarkers of depression. Neurosci Biobehav Rev. 64: 101-33. Doi.org/10.1016/j.neubiorev.2016.02.011.

Hafiane A, Genest J (2015). High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk. BBA Clinical. 3:175-88. doi.org/10.1016/j.bbacli.2015.01.005.

Hosnijeh FS, Runhaar J, van Meurs JBJ, et al (2015). Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review. Maturitas. 82:36-49. doi.org/10.1016/j.maturitas.2015.04.004.

Hu J, Yin B (2016). Advances in biomarkers of biliary tract cancers. Biomed Pharmacother. 81:128-35. doi.org/10.1016/j.biopha.2016.02.045.

Jutley GS, Young SP (2015). Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases. Best Practice Res Clin Rheumatol. 29:770-82. doi.org/10.1016/j.berh.2016.02.010.

Kallel I, Rebaı¨ M, Khabir A, Rebaı¨A (2015). What common biomarkers characterize a triple-negative profile in breast cancer? Pathologie Biologie. 63:224-9. doi.org/10.1016/j.patbio.2015.07.005.

Kanagala P, Squire IB, Ng LL, et al (2015). Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction. IJC Heart Vasculature. 9:55-62. doi.org/10.1016/j.ijcha.2015.07.004.

Kawata K, Liu CY, Merkel SF, et al (2016). Blood biomarkers for brain injury: What are we measuring? Neurosci Biobehav Rev. doi.org/doi:10.1016/j.neubiorev.2016.05.009.

Kumar M, Ernani V, Owonikoko TK (2015). Biomarkers and targeted systemic therapies in advanced non-small cell lung cancer. Molecul Aspects Med. 45:55-66. doi.org/10.1016/j.mam.2015.06.009.

Kumar R, Chaudhari D, Kumar R (2015). Biomarkers of sepsis: Recent advancements. Apollo Med. 12:239-42. doi.org/10.1016/j.apme.2015.11.003.

Kumar S, Reddy PH (2016). Are circulating microRNAs peripheral biomarkers for alzheimer‟s disease? BBA - Molecul Basis Dis. doi: 10.1016/j.bbadis.2016.06.001.

Limongi D, D'Agostini C, Ciotti M (2016). New sepsis biomarkers. Asian Pac J Trop Biomed. 6: 516-9.

Llorens F, Schmitz M, Ferrer I, (2016). CSF biomarkers in neurodegenerative and vascular dementias. Progr Neurobiol. 138-140:36-53. doi.org/10.1016/j.pneurobio.2016.03.003.

Lohani O, Colvin KL, Yeager ME (2015). Biomarkers for pediatric pulmonary arterial hypertension: challenges and recommendations. Paediatr Respirat Rev. 16:225-31. doi.org/10.1016/j.prrv.2015.05.003.

Lu X, Peng Q, Wang G (2015). Discovery of new biomarkers of idiopathic inflammatory myopathy. Clin Chim Acta. 444:117-25. doi.org/10.1016/j.cca.2015.02.007.

Lucca I, de Martino M, Klatte T, Shariat SF (2015). Novel biomarkers to predict response and prognosis in localized bladder cancer. Urol Clin N Am. 42:225-33. doi.org/10.1016/j.ucl.2015.01.004.

Maestrini I, Ducroquet A, Moulin S, (2016). Blood biomarkers in the early stage of cerebral ischemia. Revue Neurologique. 172:198-219. doi.org/10.1016/j.neurol.2016.02.003.

Manzoni M, Comolli G, Torchio M, et al (2015). Circulating endothelial cells and their subpopulations: Role as predictive biomarkers in antiangiogenic therapy for colorectal cancer. Clin Colorectal Cancer. 14:11-7. doi.org/10.1016/j.clcc.2014.12.002.

Maria Luisa Tataranno ML, Serafina Perrone S, Giuseppe Buonocore G (2015). Plasma biomarkers of oxidative stress in neonatal brain injury. Clin Perinatol . 42:529-39. doi.org/10.1016/j.clp.2015.04.011.

Martin DV, Fernández MS, Gómez JLZ (2015). Biomarkers in acute coronary syndrome. IJC Metabol Endocr. 8:20-3. doi.org/10.1016/j.ijcme.2015.04.003.

Martino DJ, Saffery R, Allen KJ, (2016). Epigenetic modifications: mechanisms of disease and biomarkers of food allergy. Curr Opin Immunol. 42:9-15. doi.org/10.1016/j.coi.2016.05.005.

Matjusaitis M, Chin G, Sarnoski EA, et al (2016). Biomarkers to identify and isolate senescent cells. Ageing Res Rev. doi.org/10.1016/j.arr.2016.05.003.

Mattsson N, Carrillo MC, Dean RA, et al (2015). Revolutionizing Alzheimer‟s disease and clinical trials through biomarkers. Alzheimer’s & Dementia: Diagnosis, Assess Dis Monitoring. 1:412-9. doi.org/10.1016/j.dadm.2015.09.001.

McConathy J, Sheline YI (2015). Imaging biomarkers associated with cognitive decline: A Review. Biol Psychiatr. 77:685-92. doi.org/10.1016/j.biopsych.2014.08.024.

McMahon BA, Koyner JL (2016). Risk Stratification for acute kidney injury: Are biomarkers enough? Adv Chronic Kidney Dis. 23:167-78. .doi.org/10.1053/j.ackd.2016.03.001.

Michopoulos V, Norrholm SD, Jovanovic T (2015). Diagnostic biomarkers for posttraumatic stress disorder: Promising horizons from translational neuroscience research. Biol Psychiatr. 78:344-353. doi.org/10.1016/j.biopsych.2015.01.005.

Moingeon P (2016). Biomarkers for allergen immunotherapy “Panoromic” View. Immunol Allergy Clin N Am. 36: 161-79. doi.org/10.1016/j.iac.2015.08.004.

Moresco RN, Speeckaert MM, Delanghe JR (2015). Diagnosis and monitoring of IgA nephropathy: the role of biomarkers as an alternative to renal biopsy. Autoimmun Rev. 14:847-53. doi.org/10.1016/j.autrev.2015.05.009.

Moschino L, Zanconato S, Bozzetto S, et al (2015). Childhood asthma biomarkers: present knowledge and future steps. Paediatr Respirat Rev. 16:205-12. doi.org/10.1016/j.prrv.2015.05.001.

Nathan N, Corvol H, Amselem S, et al (2015). Biomarkers in interstitial lung diseases. Paediatr Respirat Rev. 16:219-24. doi.org/10.1016/j.prrv.2015.05.002.

O‟Neill S, Bohl M, Gregersen S, et al (2016). Blood-based biomarkers for metabolic syndrome. Trends Endocrinol Metabol. 27:363-74. doi.org/10.1016/j.tem.2016.03.012.

Odegard JM, Nepom GT, Wambre E (2015). Biomarkers for antigen immunotherapy in allergy and type 1 diabetes. Clin Immunol. 161:44-50. doi.org/10.1016/j.clim.2015.05.023.

Parthasarathy P, Agarwal A, Chawla K, et al (2015). Upcoming biomarkers for the diagnosis of Kawasaki disease: A review. Clin Biochem. 48:1188-94. doi.org/10.1016/j.clinbiochem.2015.02.013.

Patelis N, Kouvelos GN, Koutsoumpelis A, et al (2016). An update on predictive biomarkers for major adverse cardiovascular events in patients undergoing vascular surgery. J Clin Anesthesia. 33:105-16. doi.org/10.1016/j.jclinane.2016.03.021.

Penadés R, García-Rizo C, Bioque M, et al (2015). The search for new biomarkers for cognition in schizophrenia. Schizophren Res: Cognit. 2:172-8. doi.org/10.1016/j.scog.2015.10.004.

Prucha M, Bellingan G, Zazula R (2015). Sepsis biomarkers. Clin Chim Acta. 440:97-103. doi.org/10.1016/j.cca.2014.11.012.

Rahimian P, He JJ (2015). HIV/neuroAIDS biomarkers. Progr Neurobiol. doi.org/10.1016/j.pneurobio.2016.04.003.

Ramsey KA, Schultz A, Stick SM (2015). Biomarkers in paediatric cystic fibrosis lung disease. Paediatr Respirat Rev. 16: 213-8. doi.org/10.1016/j.prrv.2015.05.004.

Richards AM (2015). Biomarkers for Heart Failure in Asia. Heart Failure Clin. 11:551-61. doi.org/10.1016/j.hfc.2015.07.007.

Scotton C, Passarelli C, Neri M, et al (2014). Biomarkers in rare neuromuscular diseases. Exp Res. 325:44-49. doi.org/10.1016/j.yexcr.2013.12.020.

Siegal T (2015). Clinical impact of molecular biomarkers in gliomas. J Clin Neurosci. 22:437-44. doi.org/10.1016/j.jocn.2014.10.004.

Siemionow QK, Teul J, Dra˛gowski P, et al (2016). New potential biomarkers of acetaminophen-induced hepatotoxicity. Adv Med Sci. doi.org/10.1016/j.advms.2016.05.001.

Silva MLS (2015). Cancer serum biomarkers based on aberrant post-translational modifications of glycoproteins: Clinical value and discovery strategies. Biochim Biophys Acta. 1856:165-77. doi.org/10.1016/j.bbcan.2015.07.002.

Skevaki C, den Berg JV, Jones N, et al (2016). Immune biomarkers in the spectrum of childhood noncommunicable diseases. J Allergy Clin Immunol. 137:1302-16. doi.org/10.1016/j.jaci.2016.03.012.

Slovin SF (2016). Biomarkers for immunotherapy in genitourinary malignancies. Urol Oncol: Seminars Original Investigat. 34:205-13. doi.org/10.1016/j.urolonc.2015.02.007.

Sridharan DM, Asaithamby A, Blattnig SR, et al (2016). Evaluating biomarkers to model cancer risk post cosmic ray exposure. The End-to-end J. 10.1016/j.lssr.2016.05.004.

Sundararajan T, Tesar GE, Jimenez XF (2016). Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review. Seizure. 35:11-22. doi.org/10.1016/j.seizure.2015.12.011.

Tse E, Kwong Y-L (2015). T-cell lymphoma: Microenvironment-related biomarkers. Seminars Cancer Biol. 34:46-51. doi.org/10.1016/j.semcancer.2015.06.001.

Viasus D, Rio-Pertuz GD, Simonetti AF, et al (2016). Biomarkers for predicting short-term mortality in community-acquired pneumonia: A systematic review and metaanalysis. J Infect. 72:273-82. doi.org/10.1016/j.jinf.2016.01.002.

Wang F-P, Fan Y-Q, Li S-Y, (2016). Biomarkers of in vivo fluorescence imaging in allergic airway inflammation. Molecul Cellul Probes. 30:100-5. doi.org/10.1016/j.mcp.2016.02.008.

Wang J, Schipper HM, Velly AM, et al (2015). Salivary biomarkers of oxidative stress: A critical review. Free Radic Biol Med. 85:95-104. doi.org/10.1016/j.freeradbiomed.2015.04.005.

Waring P, Tie J, Maru D, Karapetis CS (2015). RAS mutations as predictive biomarkers in clinical management of metastatic colorectal cancer. Clin Colorectal Cancer.15:95-103. doi.org/10.1016/j.clcc.2015.10.006.

Wasung ME, Chawla LS, Madero M (2015). Biomarkers of renal function, which and when? Clin Chim Acta. 438:350-7. doi.org/10.1016/j.cca.2014.08.039.

Wettersten N, Maisel AS (2016). Biomarkers for heart failure: An update for practitioners of internal medicine. The American Journal of Medicine. 129:560-7. doi.org/10.1016/j.amjmed.2016.01.013.

Willebrords J, Pereira IVA, Maes M, (2015). Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Progr Lipid Res. 59:106-25. doi.org/10.1016/j.plipres.2015.05.002.

Winer AG, Motzer RJ, Hakimi AA (2016). Prognostic biomarkers for response to vascular endothelial growth factor–Targeted therapy for renal cell carcinoma. Urol Clin N Am. 43: 95-104. doi.org/10.1016/j.ucl.2015.08.009.

Witteles RM (2016). Biomarkers as predictors of cardiac toxicity from targeted cancer therapies. J Cardiac Failure. 22:459-64. doi.org/10.1016/j.cardfail.2016.03.016.

Woldemichael BT, Mansuy IM (2016). Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics. Biochem Pharmacol. 104: 1-7. doi.org/10.1016/j.bcp.2015.11.021.

DOI: http://dx.doi.org/10.21477/ijapsr.v1i3.11337


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a creativecommons.org/licenses/by/4.0/. https://creativecommons.org/licenses/by/4.0/
Based on a work at http://www.sierrajournals.com/direct/index.php/IJAPSR/issue/archive