Antiulcer Effect of Formulation of Aloe Vera & Liquorice Againt Aspirin Induced Peptic Ulcer.

V. Tejasvi Reddy, S. Hari Hara Kumar, Dr. Vasudha Bakshi

Abstract


Gastric ulcers are the bowel diseases which develop chronically through a span of time because of acidity and disorderliness in eating habits as well. Following work is the novel approach to evaluate the antiulcer activity of the aloe vera and liquorice herbal formulation which never been reported before. The anti-ulcer activity of Herbal formulation of Aloe Vera and Liquorice was studied in rats and was compared with Omeprazole as standard. Ulcers were induced in rats by means of aspirin. The Anti-ulcer Herbal formulation is having significant activity against aspirin induced animal models used.  


Keywords


Antiulcer; Effect; Formulation;Aloe Vera; Liquorice; Aspirin; Induced; Peptic Ulcer.

Full Text:

PDF

References


Allen A, Flemström G, Garner A, Kivilaakso E. Gastroduodenal mucosal protection. Physiol Rev. 1993; 73:823–857.

Ariyphisi I, Toshiharu A, Sugimura F, Abe M, Matsuo Y, Honda T (1986). Recurrence during maintenance therapy with histamine H2 receptors antagonist in cases of gastric ulcers. Nikon University J Medical. 28: 69-74.

Flemstrom G, Garner A. Gastroduodenal HCO3(-) transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol. 1982;242:G183–G193.

GP. Choudhary (2012). Anti-ulcer activity of the ethanolic extract of Terminalia belerica Roxb. International Journal of Pharmaceutical and Chemical Sciences. 1(4): 1293-1297.

Kedika, R. R., Souza, R. F., & Spechler, S. J. (2009). Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications. Digestive Diseases and Sciences, 54(11), 2312–2317. http://doi.org/10.1007/s10620-009-0951-9.

Kumar Anil, Dora Jyotsna (2012). Review on Glycyrrhiza Glabra (Liquorice). Journal of Pharmaceutical and Scientific Innovation. 1(2): 1-4.

Lakshmi T, Geetha R.V (2011). Glycyrrhiza Glabra Linn commonly known as Licorice: A Therapeutic Review. International Journal of Pharmacy and Pharmaceutical Sciences. 3(4): 20-25.

Metowogo, K., Eklu-Gadegbeku, K., Agbonon, A., A. Aklikokou, K., & Gbeassor, M. (2011). Gastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri. Iranian Journal of Pharmaceutical Research : IJPR, 10(1), 69–74.

Raju D. et al (Evaluation of Anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats. J. Pharm. Sci & Res. 3: 101.

R. Rajeswari, M. Umadevi et al (2012). Aloe Vera: The Miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry. 1(4): 118-124.

Sairam K, Rao CV, Goel RK (2001a). Effect of Centella asiatica linn on physical and chemical factors induced gastric ulceration and secretion. Indian J Exp. Biol. 39: 137-142.

Sairam K, Rao CV, Goel RK (2001b). Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J Exp. Biol. 39: 350-356.

Sunil Garg, Kishan Pal, Alok Sharma, Kavita Garg (2014). Ethanopharmacological evaluation of antiulcer activity of Caralluma attenuta. Int. J. of Pharm. Life Sci. 5(6):3585-3589.

Wang, Z., Hasegawa, J., Wang, X., Matsuda, A., Tokuda, T., Miura, N., & Watanabe, T. (2011). Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. Yonago Acta Medica, 54(1), 11–19.




DOI: http://dx.doi.org/10.21477/ijapsr.v1i1.10174

Refbacks



Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Creative Commons License
International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at http://www.sierrajournals.com/direct/index.php/IJAPSR/issue/archive.