DEVELOPMENT AND IN-VITRO EVALUATION OF CEFPODOXIME PROXETIL GASTRO-RETENTIVE FLOATING TABLETS

Chintanippula Sai Rama Rao, Sharath K, Kowmudi V, Suresh N

Abstract


The present study was undertaken with the aim to develop and evaluate Gastro retentive floating tablets of Cefpodoxime proxetil to get drug release up to 12hrs. These tablets were prepared by direct compression method using various bioadhesive polymers like HPMC K4M,  HPMC K100M.The formulated gastro retentive floating tablets were evaluated for different parameters such as drug excipient compatability studies, weight variation, thickness, hardness, content uniformity, Invitro Buoyancy studies, In vitro drug release studies performed in 0.1N HCl for 12hrs  and the data was subjected to zero order, first order, Higuchi release kinetics and kars mayer peppas graph. All pre and post compression parameters were found to be within limits. From the drug release data among formulations, F8 formulation was found to be optimized when compared with standard/marketed.


Keywords


DEVELOPMENT; IN-VITRO EVALUATION; CEFPODOXIME PROXETIL; GASTRO-RETENTIVE; FLOATING TABLETS;

Full Text:

PDF

References


Abdul BA, Lila KN (2011). Fabrication and in vitro evaluation of floating matrix tablet of nicorandil using factorial design. J Pharm Res. 4(6), 1950-4.

Akiyama Y, Nagahara N, Kashihara T, Hirai S, Toguchi H (1995). In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly (acrylic acid) derivative. Pharm. Res. 12, 397-405.

Borin T (1991). A review of the pharmacokinetics of cefpodoxime proxetil. Drugs. 42, 13–21.

B. Ramu, N. Ramakrishna, Meruva Sathish, D. Anoosha (2015). Formulation of tellmisartan Hcl Fast Disintegrating Tablets by Sublimation Technique. International Journal of Pharm Tech Research. 8(3), 330-339.

Crauste-Manciet S, Huneau JF, Decroix MO, Tome D, Chaumeil JC (1997). Cefpodoxime proxetil esterase activity in rabbit small intestine: role in the partial cefpodoxime absorption. Int. J. Pharm. 149, 241–249.

Deshpande AA, Rhodes CT, Shah NH, Malick AW (1996). Controlled-release drug delivery systems for prolonged gastric residence: an overview. Drug Dev. Ind. Pharm. 22, 531-539.

Fix JA, Cargill R, Engle K (1993). Controlled gastric emptying: part3. Gastric residence time of a nondisintegrating geometric shape in human volunteers. Pharm. Res. 10, 1087-1089.

Groning R, Berntgen M, Georgarakis M (1998). Acyclovir serum concentrations following peroral administration of magnetic depot tablets and the influence of extracorporeal magnets to control gastrointestinal transit. Eur. J. Pharm. Biopharm. 46, 285-291.

Hamamura T, Kusai A, Nishimura K (1995a). Gel formation of cefpodoxime proxetil. S.T.P. Pharm. Sci. 5, 324–331.

Hamamura T, Ohtani T, Kusai A, Nishimura K (1995b). Unusual dissolution behavior of cefpodoxime proxetil: effect of pH and ionic factors. S.T.P. Pharm. Sci. 5:332–338.

Hamamura T, Terashima H, Ohtani T (1995c). Decrease in dissolution of cefpodoxime proxetil tablets by gel formation and its improvement. Yakuzaigaku. 55, 175–182.

Hareesh Dara, Narasimha Reddy Yellu (2015). Formulation of Time Dependent Controlled Release Tablet of Nimodipine and its Evaluation using Linear Regression Analysis. Journal of Pharma Research. 4(1), 1-8.

Hughes GS, Heald DL, Barker KB (1989). The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin. Pharmacol. Ther. 46, 674–85.

Hwang SJ, Park H, Park K (1998). Gastric retentive drug-delivery systems. Crit. Rev. Ther. Drug Carr. Syst. 15, 243-284.

Kakumanu VK, Arora V, Bansal AK (2006). Investigation of factors responsible for low oral bioavailability of cefpodoxime proxetil. Int. J. Pharm. 317, 155–160.

Kaza R, Usharani E, Nagaraju R, Haribabu R, Reddy PVS (2009). Design and evaluation of sustained release floating tablets for the treatment of gastric ulcers. J Pharm Sci Res. 1(4), 81-7.

Lachman L, Liberman HA, Kanig JL (1990). The theoty and practive of industrial pharmacy, tablets. 3rd ed. Mumbai: Varghese Publishing House; pp. 293-302.

Lee JH, Park TG, Choi HK (1999). Development of oral drug delivery system using floating microspheres. J. Microencapsul. 16, 715-729.

Moes AJ (1993). Gastro retentive dosage forms. Crit. Rev. Ther. Drug Carr. Syst. 10, 143-195.

Park K (1988). Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery: synthesis and characterization. Biopharm. 46, 285-291.

Rouge N, Cole ET, Doelker E, and Buri P (1998). Buoyancy and drug release patterns of floating minitablets containing piretanide and atenolol as model drugs. Pharm. Dev. Technol. 3, 73-84.

Rosa M, Zia H, Rhodes T (1994). Dosing and testing in-vitro of a bioadhesive and floating drug delivery system for oral application. Int J Pharm. 105, 65-70.

Tripathi G, Singh S (2010). Formulation and In Vitro evaluation of pH sensitive oil entrapped polymeric blended gellan gum buoyant beads of clarithromycin. Daru. 18, 247-253.

Yuasa H, Takashima Y, Kanaya Y (1996). Studies on the development of intragastric floating and sustained release preparation: I. Application of calcium silicate as a floating carrier. Chem. Pharm. Bull. 44, 1361-1366.




DOI: http://dx.doi.org/10.21477/ijapsr.v1i1.9606

Refbacks



Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Creative Commons License
International Journal of Applied Pharmaceutical Sciences and Research by Sierra Journals is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at http://www.sierrajournals.com/direct/index.php/IJAPSR/issue/archive.